منابع مشابه
Cells need backward motor to move forward
Cells need backward motor to move forward ytoplasmic dynein associates with a variety of intracellular cargos and pulls them toward the minus ends of microubules. But this retrograde motor protein is also essential for forward cell migration, as Dujardin et al. demonstrate on page 1205. After observing dynein and its associated regulatory proteins at the leading edges of migrating cells in a mo...
متن کاملBackward waves move cells forward
dvancing cells periodically pull on their substrates to test the environment, say Grégory Giannone, Michael Sheetz (Columbia University, New York, NY), and colleagues. The actomyosin contractions both strengthen attachments to more solid substrates, and break off part of a signaling complex so that it can be carried into the cell. Once that retrograde signal reaches myosin, which is some distan...
متن کاملPulling Back to Move Forward
Animal cells can change shape and move by using actin polymerization to drive plasma membrane protrusion. Giannone and coworkers (this issue of Cell) describe how cells periodically pull back on these protrusions in order to sense and respond to the rigidity of their environment.
متن کاملHerpes Simplex Virus Type 1 for Use in Cancer Gene Therapy: Looking Backward to Move Forward
Herpes simplex virus type 1 (HSV-1) belongs to the Herpesviridae family, Alphaherpesvirinae subfamily. HSV-1 is a human pathogen associated with keratitis and cold sores, the formation of which is exacerbated by periods of elevated stress, corticosteroid use and immunosuppression. HSV-1 is an enveloped double stranded DNA (dsDNA) virus which following primary infection in epithelial cells follo...
متن کاملLooking Forward to Looking Backward
Decisions are powerfully affected by anticipated regret, and people anticipate feeling more regret when they lose by a narrow margin than when they lose by a wide margin. But research suggests that people are remarkably good at avoiding self-blame, and hence they may be better at avoiding regret than they realize. Four studies measured people’s anticipations and experiences of regret and self-b...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 2003
ISSN: 1540-8140,0021-9525
DOI: 10.1083/jcb1636iti3